Epitalon

Synthetic tetrapeptide studied in telomerase-activity and cellular-aging models. For in-vitro research only.

• Added to telomerase-negative human fetal fibroblast culture the peptide induced expression of the telomerase catalytic subunit, enzymatic activity of the telomerase and elongation of telomeres. [1]
• A later study across normal epithelial and fibroblast cells and two breast cancer lines reported concentration dependent telomere extension, through hTERT and telomerase upregulation in the normal cells and through alternative lengthening of telomeres in the cancer lines. [2]
• Mass spectrometry and HPLC of the pineal polypeptide complex resolved its peptide length distribution and detected this tetrapeptide among the tetrapeptide fraction by selective reaction monitoring. [3]
• In human gingival mesenchymal stem cells the peptide raised four neurogenic differentiation markers at both mRNA and protein level, and molecular modelling placed its preferred binding at two named sites of histones H1/3 and H1/6 that contact DNA. [4]

Compound

Epitalon

Purity

99.40% (HPLC)

Identity

Confirmed by MS

Appearance

White lyophilate

Presentation

10 mg

Catalog / lot

RV-0043 / RV-24-0043-1

For research use only. Not for human or veterinary use. Not a drug, food, cosmetic, or supplement.

Review the laboratory, lot identifier, and reported results in this document. Keep the lot identifier with your research records.