SS-31

SS-31 research material, available in 10 mg, 50 mg vials. For in-vitro research only.

• A polarity-sensitive fluorescent analogue of the peptide bound cardiolipin with high affinity, and the resulting complex inhibited cytochrome c peroxidase activity by protecting the heme iron. [1]
• Chemical cross-linking with mass spectrometry found that every mitochondrial protein interactor recovered was a known cardiolipin binder, split between oxidative phosphorylation proteins and 2-oxoglutarate metabolism proteins, with cross-linked residues often near cardiolipin contact regions. [2]
• A genome-scale CRISPR screen identified phospholipid scramblase 3 as required for the mitoprotective effect, and biochemical work showed the peptide binding a previously uncharacterized N-terminal domain of that protein and stimulating its scramblase activity. [3]
• NMR and molecular dynamics models of the membrane-bound state show that three related analogues form compact reverse turns while this peptide does not, and the four differ in equilibrium binding and in their effect on membrane surface charge. [4]

Compound

SS-31

Purity

99.60% (HPLC)

Identity

Confirmed by MS

Appearance

White lyophilate

Presentation

10 mg · 50 mg

Catalog / lot

RV-0013 / RV-24-0013-1

For research use only. Not for human or veterinary use. Not a drug, food, cosmetic, or supplement.

Review the laboratory, lot identifier, and reported results in this document. Keep the lot identifier with your research records.