L-Carnitine

L-carnitine research material, available in 600 mg and 1200 mg vials. For in-vitro research only.

• Transport across the apical membrane of enterocytes and brush-border membrane vesicles was sodium-dependent, voltage-dependent and pH-dependent, with a Km of 26 to 31 micromolar and a one-to-one sodium to carnitine stoichiometry. [1]
• Inhibition studies in the same preparations ranked the competing substrates, with unlabeled L-carnitine above D-carnitine, acetyl-L-carnitine and gamma-butyrobetaine, which in turn exceeded palmitoyl-L-carnitine and betaine, while alanine, histidine and choline had no significant effect. [1]
• Structural requirements for inhibiting the human transporter, established in L6 cells stably overexpressing it, were a permanently positively charged nitrogen atom plus a carboxyl, nitrile or ester group joined by a two to four atom linker. [2]
• Crystal structures of two carnitine acyltransferases place carnitine and coenzyme A in deep channels on opposite sides of the catalytic histidine, and show that a single residue in the acyl binding pocket shifts substrate preference between short and medium chain acyl groups. [3] [4]

Compound

L-Carnitine

Purity

99.10% (HPLC)

Identity

Confirmed by MS

Appearance

White lyophilate

Presentation

600 mg · 1200 mg

Catalog / lot

RV-0016 / RV-24-0016-2

For research use only. Not for human or veterinary use. Not a drug, food, cosmetic, or supplement.

Review the laboratory, lot identifier, and reported results in this document. Keep the lot identifier with your research records.